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NSAIDs demper denne reaksjonen ved å hindre dannelse av en gruppe betennelsesfremkallende stoffer kalt prostaglandiner. Denne effekten kan være svært gunstig ved smerter i muskel og skjelett eller andre smertetyper hvor betennelse er en viktig årsak til smerten. Eit epileptisk anfall varar sjeldan lenger enn two minutt. Enkelte gongar kan